ABSENCE OF ATG9A AND SYNAPTOPHYSIN DEMIXING ON RAB5 MUTATION-INDUCED GIANT ENDOSOMES

Abstract ATG9A is the only integral membrane protein among core autophagy-related (ATG) proteins.We previously found that ATG9A does not co-assemble into synaptophysin-positive vesicles, but rather, localizes to a Hand Strap distinct pool of vesicles within synapsin condensates in both fibroblasts and nerve terminals.The endocytic origin of these v